At admission to hospital in all children we detected clinical laboratory and anamnestic data, which did not exclude AP. At the same time only 124 patients (62%) had clinical laboratory diagnosis “AP” or “aggravation of chronic pyelonephritis” prior to the first Biophilia NLS. In other cases indications for Biophilia NLS-study were: acute appendicitis – 30 patients (15%); urinary tract infections – 20 (10%); ARVI with abdominal syndrome – 16 (8%); nephrocolic – 6 (3%); renal impaired development – 2 (1%); kidney trauma – 2 (1%). Disease period was from 14 hours to 6 days before the first Biophilia NLS.

Along with Biophilia NLS, laboratory studies of blood and urine, all patients were administered to Biophilia NLS- ultramicroscanning with SEA. Surgical intervention (kidney revision) was carried out in 6 cases, indication for the intervention were symptoms of local or polyorganic spreading of purulent-destructive changes detected by Biophilia NLS-ultramicroscanning with SEA. We evaluated changes of renal and paranephral structures during surgery. In 4 cases we acquired fragments of tissues for histological study.