At the same time we should emphasize the following factor. The first two categories of RC regional invasion criteria and symptoms of tumor invasion into neighboring organs are characterized by the clear dependence of symptoms revealing frequency from size of the primary tumor with maximum values at tumors above 70 mm size. Symptoms of regional metastasis and symptoms of thrombogenesis or invasion into renal vein or inferior vena cava were registered more frequently at size of primary tumor from 41 to 70 mm (24.8%) and from 20 to 40 mm (14%) correspondingly.

Besides we should note a possibility to reveal signs of regional spreading of a primary tumor of less than 10 mm size by bioplasm 9d nls analyzer-ultramicroscanning with SEA. In single cases of such tumors we registered an invasion into kidney’s cavitary system (0.8%), extrarenal spreading (1.2%) and symptoms of regional metastasis (2.8% of cases).

The following clinical observation is an example.