purulent-exudative (pre-destructive). It differs from the previous one by manifestation in parenchyma where edematic-infiltrative manifestations are the most signoficant, hyperchromogenic nidi (6 points at Fleindler’s scale) of irregular shape and small size (not more than 1-2-4 mm at the initial detection), associated with areas of purulent exudation. They have no strict location, and are visualized both in medullar and cortical areas of parenchyma with prevailing affection of the latter. At Bioplasm NLS-ultramicroangiography we saw significant affection of bloodstream in these exudative (pre-destructive) nidi.

It must be noted that this stage is a short one – from several hours to 1 or 2 days; it does not correlate with any clinical-laboratory manifestations of the disease, especially with the background of anti-bacterial treatment. In relation to AP pathomorphogenesis stages, this stage may be considered as a border-line between purulent non-destructive (exudative) process and a beginning of nidal lysis of tissues. A tendency to increased sized of detected pre-destructive nidi and decreasing of their chromogeneity (i.e. further “softening”) evidences about transition to a stage of destruction.