To identify Crohn’s disease degree of activity a Best’s index is used. Except Best’s index there are also conditional biological markers of expressiveness of inflammatory process, such as C-reactive protein, erythrocyte sedimentation rate, number of platelets, fibrinogens, and also endoscopic and contrast methods of research. However instrumental methods of investigation have the lacks related to a risk of disease aggravation during preparation for given inspection and an irradiation. Bioplasm nls software-diagnostics method has no such flaws.