In group of malignant tumors of liver, metastatic invasion holds leading positions. It is well-known that the most frequent reasons for liver metastatic disease are malignant tumors of the large intestine, rectum, stomach, pancreas, mammary glands and lungs. At metastatic disease, the shape, structure, size of parenchyma and vascular pattern of the liver are more or less changed, depending on tumor existence duration, as well as number and size of tumoral nodes. In addition to three-dimensional NLS-graphy, diverse variants of dopplerography (initially energy color mapping) may be used to solve the problem of differential diagnostics of benign and malignant changes in the liver parenchyma. Three-dimensional NLS-graphy method allows the visualization of a three-dimensional picture of vessel location and form, marking them by a certain color in the background of the organ’s normal picture. In this aspect, the method is rather close to x-ray angiography and allows to accurately visualize large and minute vessels.