Fibrogastroduodenoscopy and three-dimensional Bioplasm machine  have a significant importance in diagnostics of major duodenal papilla tumors. Endoscopic picture of the cancer at late stages is quite typical: tuberiferous tumor of red or crimson color, occupying a part or whole major duodenal papilla.

Due to similar density values of major duodenal papilla cancer and surrounding bile, application of computed tomography cannot visualize this lesion, especially when a tumor is small and bile and pancreatic ducts are not dilated. But CT is more precisely, in comparison with standard two-dimensional Bioplasm machine-study, identifies a side and reason of extrahepatic biliary obstruction. At major duodenal papilla cancer CT shows rupture of common bile duct and major pancreatic duct without any signs of these manifestations combination with tumorous affection. When positive contrast is used, a small defect in an area of major duodenal papilla is seen in duodenum lumen.